Cochrane Review: Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years

Zusammenfassung

# Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years. ## BACKGROUND Zinc deficiency is prevalent in low- and middle-income countries, and is considered a significant risk factor for morbidity, mortality, and linear growth failure. The effectiveness of preventive zinc supplementation in reducing prevalence of zinc deficiency needs to be assessed. ## OBJECTIVES To assess the effects of zinc supplementation for preventing mortality

Kerninformationen

ce checking and contact with study authors to identify additional studies. ## SELECTION CRITERIA Randomized controlled trials (RCTs) of preventive zinc supplementation in children aged 6 months to 12 years compared with no intervention, a placebo, or a waiting list control. We excluded hospitalize...

ry tract infection (LRTI, including pneumonia), and malaria. We also collected information on a number of secondary outcomes, such as those related to diarrhea and LRTI morbidity, growth outcomes and serum levels of micronutrients, and adverse events. ## MAIN RESULTS We included 16 new studies in ...

yses of morbidity and mortality outcomes was affected by risk of bias. High-certainty evidence showed little to no difference in all-cause mortality with preventive zinc supplementation compared to no zinc (risk ratio (RR) 0.93, 95% confidence interval (CI) 0.84 to 1.03; 16 studies, 17 comparisons, ...

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