DrugBank: Pregabalin - Pharmacological Profile

Zusammenfassung

DRUGBANK PHARMACOLOGICAL PROFILE: Pregabalin Drug Class: Gabapentinoid (Alpha-2-delta calcium channel ligand) Category: Psychiatric === MECHANISM OF ACTION === Binds to alpha-2-delta subunit of voltage-gated calcium channels, reducing calcium influx and excitatory neurotransmitter release (glutamate, norepinephrine, substance P). Not a GABA analog despite structural similarity. === INDICATIONS === - Neuropathic pain (diabetic, post-herpetic) - Fibromyalgia - Generalized anxiety disorder - Epi

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