Cochrane Review: Long-term hormone therapy for perimenopausal and postmenopausal women

Zusammenfassung

# Long-term hormone therapy for perimenopausal and postmenopausal women. ## BACKGROUND Hormone therapy is widely provided to control menopausal symptoms and has been used for the management and prevention of cardiovascular disease, osteoporosis and dementia in older women. This is an updated version of a Cochrane review first published in 2005. ## OBJECTIVES To assess the long-term effects of prolonged use (at least one year) of hormone therapy on mortality, cardiovascular outcomes, cancer,

Kerninformationen

g and contact with study authors to identify the studies included in the review. The latest search date was 26 September 2024. ## SELECTION CRITERIA We included randomised, double-blind trials in which peri- or postmenopausal women took hormone therapy or placebo for at least one year. We included...

dichotomous data and mean differences (MDs) for continuous data, along with 95% confidence intervals (CIs). We assessed the certainty of the evidence using GRADE. ## MAIN RESULTS We included 24 studies - with two newly added in this update - involving 45,660 participants. We derived nearly 70% of ...

studies with available data in the main review. The results presented below are drawn from WHI 1998, in which the combined hormone therapy arm and the oestrogen-only arm were run concurrently, with women assigned to the appropriate trial based on their uterus status. One study with 16,608 postmenop...

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