Current and future treatment of rheumatoid arthritis

Zusammenfassung

J Rheum Dis. 2025 Oct 21;33(1):7–18. doi: 10.4078/jrd.2025.0034 Current and future treatment of rheumatoid arthritis Jin Kyun Park Jin Kyun Park, M.D., Ph.D. 1Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Find articles by Jin Kyun Park 1, Byeongzu Ghang Byeongzu Ghang, M.D., Ph.D. 2Division of Rheumatology, Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju,

Kerninformationen

The pathogenesis of RA involves a complex interplay of genetic predisposition and environmental factors, such as smoking, which together drive the dysregulated activation of both the innate and adaptive immune systems. The introduction of disease-modifying antirheumatic drugs marked a pivotal advanc...

The introduction of DMARDs marked a pivotal turning point in the management of RA, transforming it from a debilitating and painful chronic condition into a treatable disease, offering the possibility of long-term remission and improvement in quality of life. Ongoing advancement in basic and clinical...

The introduction of tumor necrosis factor (TNF)-alpha inhibitor (TNFi) as the first biological DMARD (bDMARD) in 1992 was a breakthrough in RA treatment [11]. It neutralized the key inflammatory cytokine TNF in RA, providing immediate symptom relief. TNFi was soon followed by other bDMARDs targeting...

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