Cochrane Review: Shortened treatment regimens versus the standard regimen for drug-sensitive pulmonary tuberculosis

Zusammenfassung

# Shortened treatment regimens versus the standard regimen for drug-sensitive pulmonary tuberculosis. ## BACKGROUND Tuberculosis causes more deaths than any other infectious disease worldwide, with pulmonary tuberculosis being the most common form. Standard first-line treatment for drug-sensitive pulmonary tuberculosis for six months comprises isoniazid, rifampicin, pyrazinamide, and ethambutol (HRZE) for two months, followed by HRE (in areas of high TB drug resistance) or HR, given over a fou

Kerninformationen

men for individuals with drug-sensitive pulmonary tuberculosis. ## SEARCH METHODS We searched the following databases up to 10 July 2019: the Cochrane Infectious Diseases Group Specialized Register; the Central Register of Controlled Trials (CENTRAL), in the Cochrane Library; MEDLINE (PubMed); Emb...

oing trials. We checked the reference lists of identified articles to find additional relevant studies. ## SELECTION CRITERIA We searched for randomized controlled trials (RCTs) or quasi-RCTs that compared shorter-duration regimens (less than six months) versus the standard six-month regimen for p...

ratios (RRs) with 95% confidence intervals (CIs). When appropriate, we pooled data from the included trials in meta-analyses. We assessed the certainty of evidence using the GRADE approach. ## MAIN RESULTS We included five randomized trials that compared fluoroquinolone-containing four-month ATT ...

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