ECCO Guidelines on Ulcerative Colitis Management (2021)

Zusammenfassung

# ECCO GRADE Guidelines: Ulcerative Colitis Management 2021 ## Introduction Ulcerative colitis (UC) is a chronic inflammatory condition affecting the colon. ECCO guidelines provide evidence-based recommendations for diagnosis and management. ## Classification ### Montreal Classification (Extent) - **E1 (Proctitis):** Limited to rectum (<15cm from anal verge) - **E2 (Left-sided):** Up to splenic flexure - **E3 (Extensive/Pancolitis):** Beyond splenic flexure ### Disease Severity (Mayo Score)

Kerninformationen

## Classification ### Montreal Classification (Extent) - **E1 (Proctitis):** Limited to rectum (<15cm from anal verge) - **E2 (Left-sided):** Up to splenic flexure - **E3 (Extensive/Pancolitis):** Beyond splenic flexure ### Disease Severity (Mayo Score) - **Remission:** 0-2 (no subscore >1) - **Mi...

## Induction Therapy ### Mild to Moderate UC #### Proctitis (E1) - Mesalazine suppositories 1g daily (first-line) - Add oral mesalazine if insufficient - Topical steroids as second-line #### Left-sided (E2) - Mesalazine enemas + oral mesalazine - Minimum 2-4g oral mesalazine - Topical steroids if...

## Maintenance Therapy ### 5-ASA (first-line maintenance) - Oral mesalazine ≥2g daily - Topical therapy maintains proctitis effectively - Combination oral + topical superior to either alone ### Thiopurines - Azathioprine 2-2.5 mg/kg for steroid-dependent patients - Check TPMT, monitor blood counts...

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