ATS/CDC/IDSA: Treatment of Drug-Resistant and Drug-Susceptible TB (2025)

Zusammenfassung

Abstract Background: On the basis of recent clinical trial data for the treatment of drug-susceptible and drug-resistant tuberculosis (TB), the American Thoracic Society, U.S. Centers for Disease Control and Prevention, European Respiratory Society, and Infectious Diseases Society of America have updated clinical practice guidelines for TB treatment in children and adults in settings in which mycobacterial cultures, molecular and phenotypic drug susceptibility tests, and radiographic studies, am

Kerninformationen

xacin followed by 2 months of isoniazid, rifapentine, and moxifloxacin (2HPZM/2HPM) as efficacious and safe as the standard 6-month drug-susceptible TB regimen of 2 months of isoniazid, rifampin, pyrazinamide, and ethambutol (2HRZE) followed by 4 months of isoniazid, and rifampin (4HR) endorsed by t...

ere TB is defined as peripheral lymph node TB; intrathoracic lymph node TB without airway obstruction; uncomplicated TB pleural effusion; or paucibacillary and noncavitary disease confined to one lobe of the lungs or without a miliary pattern. Children and adolescents who do not meet the criteria fo...

ampin-resistant pulmonary TB Question: In adolescents aged 14 and older and adults with rifampin-resistant, fluoroquinolone-susceptible pulmonary TB, is a 6-month BPaLM regimen as effective and safe as the 15-month or longer drug-resistant TB regimens composed according to current ATS/CDC/ERS/IDSA D...

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