DrugBank: Metformin - Pharmacological Profile

Zusammenfassung

DRUGBANK PHARMACOLOGICAL PROFILE: Metformin Drug Class: Biguanide antidiabetic Category: Endocrine === MECHANISM OF ACTION === Reduces hepatic glucose production, increases insulin sensitivity in peripheral tissues, delays intestinal glucose absorption. Does not stimulate insulin secretion (no hypoglycemia as monotherapy). Also activates AMPK pathway. === INDICATIONS === - Type 2 diabetes mellitus (first-line) - PCOS (off-label) - Prediabetes/diabetes prevention === CONTRAINDICATIONS === - e

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