Cochrane Review: Prevention of infection in peripheral arterial reconstruction of the lower limb

Zusammenfassung

# Prevention of infection in peripheral arterial reconstruction of the lower limb. ## BACKGROUND Peripheral arterial disease (PAD) results from the narrowing of arteries. Arterial reconstruction surgery is the treatment of choice for severe cases. Graft infections and surgical site infections (SSIs) are a feared and common complication of vascular surgery. These infections have a significant global healthcare impact. Evaluating the effectiveness of preventive measures is essential. ## OBJECTI

Kerninformationen

lar Information Specialist searched the Cochrane Vascular Specialised Register, CENTRAL, MEDLINE, Embase, LILACS, and CINAHL databases, as well as the World Health Organization International Clinical Trials Registry Platform and ClinicalTrials.gov up to 26 August 2024. ## SELECTION CRITERIA We inc...

nty of evidence using the GRADE approach. ## MAIN RESULTS We included 35 RCTs and five quasi-RCTs with a total of 7970 participants. We analysed 16 comparisons for nine outcomes. The four main comparisons were prophylactic antibiotics versus placebo or no treatment; short- (≤ 24 hours) versus long...

events resulting from the interventions to prevent infection. Not all outcomes were assessed across the different comparisons. Prophylactic antibiotics versus placebo (eight studies) Low-certainty evidence from eight included studies suggests that antibiotic prophylaxis may reduce the graft infectio...

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