Cochrane Review: Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care

Zusammenfassung

# Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care. ## BACKGROUND Opioid-induced bowel dysfunction (OIBD) is characterised by constipation, incomplete evacuation, bloating, and gastric reflux. It is one of the major adverse events (AEs) of treatment for pain in cancer and palliative care, resulting in increased morbidity and reduced quality of life. This review is a partial update of a 2008 review, and critiques as previous u

Kerninformationen

gical/non-pharmacological interventions, placebo, or no treatment. ## SEARCH METHODS We searched CENTRAL, MEDLINE, Embase, CINAHL, and Web of Science (December 2021), clinical trial registries and regulatory websites. We sought contact with MOA manufacturers for further data. ## SELECTION CRITERI...

evidence using GRADE and created summary of findings tables. ## MAIN RESULTS We included 10 studies (two new trials) randomising in-total 1343 adults with cancer irrespective of stage, or at palliative care stage of any disease. The MOAs were oral naldemedine and naloxone (alone or in combination...

nding of the outcome assessor was not reported.  Oral naldemedine versus placebo Risk (i.e. chance) of spontaneous laxations in the medium term (over two weeks) for naldemedine was over threefold greater risk ratio (RR) 2.00, 95% confidence interval (CI) 1.59 to 2.52, 2 trials, 418 partici...

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