Cochrane Review: Non-invasive ventilation for cystic fibrosis

Zusammenfassung

# Non-invasive ventilation for cystic fibrosis. ## RATIONALE People with cystic fibrosis (pwCF) may experience mucus retention, increased breathlessness, and decreased respiratory muscle strength. Non-invasive positive pressure ventilation (NIPPV) is used to treat acute and chronic respiratory symptoms in people. Studies have investigated the effects of NIPPV on airway clearance during sleep and exercise, as strategies to optimize the treatment of cystic fibrosis (CF). ## OBJECTIVES To asses

Kerninformationen

ts of included studies. ## ELIGIBILITY CRITERIA We included randomized controlled trials (RCTs) of parallel and cross-over designs that compared NIPPV with no NIPPV or other treatments in pwCF. ## OUTCOMES Our outcomes were mortality, quality of life (QoL), sleep symptoms and sleep quality, lung...

come measure, for which we used the restricted maximum likelihood (REML) method random-effects analysis. We did not perform further meta-analyses because most outcomes were reported by a single study. ## INCLUDED STUDIES Of the 14 studies included, 11 had a cross-over design and three were paralle...

THESIS OF RESULTS NIPPV for pwCF experiencing a pulmonary exacerbation The evidence is very uncertain regarding the acute effects of BiPAP (bilevel positive airway pressure), both in comparison to the PEP (positive expiratory pressure) mask (mean difference (MD) -0.06, 95% confidence interval (CI) ...

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