Cochrane Review: Interventions for the treatment of Paget's disease of the vulva

Zusammenfassung

# Interventions for the treatment of Paget's disease of the vulva. ## BACKGROUND This is an updated version of the original Cochrane Review published in Issue 10, 2013.Extramammary Paget's disease is a rare form of superficial skin cancer. The most common site of involvement is the vulva. It is seen mainly in postmenopausal white women. Paget's disease of the vulva often spreads in an occult fashion, with margins extending beyond the apparent edges of the lesion. There is a range of interventi

Kerninformationen

e most common treatment, but it is challenging to excise the disease adequately, and recurrence is common, leading to repeated operations, and destruction of anatomy. Alternative treatments of photodynamic therapy, laser therapy, radiotherapy, topical treatments or even chemotherapy have been mooted...

e also searched registers of clinical trials, abstracts of scientific meetings and reference lists of review articles. ## SELECTION CRITERIA We searched for randomised controlled trials (RCTs) and well-designed non-randomised studies that compared different interventions in women with Paget's dise...

have included a comprehensive narrative account of studies where we identified an analysis of more than 10 women, as this forms the only evidence base in this rare disease. Surgery continues to be the mainstay of treatment in the current literature, with other treatments limited to case reports or ...

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