Cochrane Review: Recombinant growth hormone therapy for X-linked hypophosphatemia in children

Zusammenfassung

# Recombinant growth hormone therapy for X-linked hypophosphatemia in children. ## BACKGROUND Conventional treatment of X-linked hypophosphatemia with oral phosphate and calcitriol can heal rickets, but it does not always raise serum phosphate concentrations significantly, nor does it always normalize linear growth. Some clinical trials suggest that combining recombinant human growth hormone therapy with conventional treatment improves growth velocity, phosphate retention, and bone mineral den

Kerninformationen

osphatemia is associated with changes in longitudinal growth, mineral metabolism, endocrine function, renal function, bone mineral density, body proportions, and also with any adverse effects. ## SEARCH METHODS We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register wh...

d controlled studies or quasi-randomized controlled studies comparing growth hormone (alone or combined with conventional treatment) with either placebo or conventional treatment alone in children with X-linked hypophosphatemia. ## DATA COLLECTION AND ANALYSIS Two authors independently assessed st...

or phosphate reabsorption. In the second, parallel study, treatment may also have improved the height SDS from baseline in the rhGH group compared to the control group, although no significant difference was seen between groups after three years, MD 0.50 SDS (95 % CI -0.54 to 1.54) (low-certainty ev...

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