Cochrane Review: Melatonin in cancer treatment

Zusammenfassung

# Melatonin in cancer treatment. ## RATIONALE Preserving health-related quality of life is an aspect of care that requires constant attention from the time of cancer diagnosis. Melatonin has been used to diminish treatment-related side effects and cancer symptoms, and as a medication to regulate circadian rhythm. An up-to-date systematic review is needed to investigate the current evidence concerning possible beneficial effects of melatonin on quality of life and sleep in cancer patients. ##

Kerninformationen

e checking, citation searching, and contact with study authors. The latest search date was 10 September 2024. ## ELIGIBILITY CRITERIA We included randomised controlled trials (RCTs) of adults (18 years or over) with histologically proven cancer of any stage that evaluated melatonin (alone or in co...

n-related adverse events. Other outcomes included survival, disease-free survival, progression-free survival, tumour response, and anticancer treatment-related harms. ## RISK OF BIAS We used Cochrane's risk of bias tool (RoB 1) to assess the risk of bias in the studies included in the review. ## ...

g 5093 adult participants with cancer (2470 males, 2228 females, 395 not reported). Studies were conducted in a hospital setting and took place in at least 10 countries. We assessed two studies at low risk of bias and the other 28 at high risk of bias. ## SYNTHESIS OF RESULTS Melatonin plus standa...

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