Cochrane Review: Early discontinuation of antibiotics for febrile neutropenia versus continuation until neutropenia resolution in people with cancer

Zusammenfassung

# Early discontinuation of antibiotics for febrile neutropenia versus continuation until neutropenia resolution in people with cancer. ## BACKGROUND People with cancer with febrile neutropenia are at risk of severe infections and mortality and are thus treated empirically with broad-spectrum antibiotic therapy. However, the recommended duration of antibiotic therapy differs across guidelines. ## OBJECTIVES To assess the safety of protocol-guided discontinuation of antibiotics regardless of n

Kerninformationen

ith people with cancer treated until resolution of neutropenia. ## SEARCH METHODS We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2018, Issue 10) in the Cochrane Library, MEDLINE, Embase, and LILACS up to 1 October 2018. We searched the metaRegister of Controlled Trials an...

rdless of the neutrophil count to a long course in which antibiotics were continued until neutropenia resolution in people with cancer with febrile neutropenia. The primary outcome was 30-day or end of follow-up all-cause mortality. ## DATA COLLECTION AND ANALYSIS Two review authors independently ...

y was found, trials were pooled using the Mantel-Haenszel fixed-effect model. ## MAIN RESULTS We included eight RCTs comprising a total of 662 distinct febrile neutropenia episodes. The studies included adults and children, and had variable design and criteria for discontinuation of antibiotics in...

Fragen zu diesem Thema?

ClariMed durchsucht alle Leitlinien mit KI und liefert quellenbasierte Antworten in Sekunden.

Jetzt auf ClariMed suchen